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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| MO18006 | 100 ul | $275.00 | Buy Now | Add to Cart |
CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways.
Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2 (7-9).
Image: Confocal immunofluorescent analysis of mouse dentate gyrus stained with Tau (red) and CREB (blue).
Image: Western blot analysis of extracts from 293, COS and PC12 cells, using CREB
Related Reagents to Consider:
CLAC-P (NC2-1 Region) (RA19007)
CLAC-P (NC2-2 Region) (RA19008)