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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| GT15073 | 100 ug | $345.00 | Buy Now | Add to Cart |
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.
Images: Paraffin-embedded tissue sections of human pituitary were stained with anti-human TGF-beta RII using ABC-HRP, NovaRed (red) substrate and Haematoxylin (blue) counterstain.
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Image: Detection of TGF beta RII in Human small intestine lysates.