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Antibodies

Met-Enkephalin

Affinity Purified Rabbit Antibody
DATASHEET(pdf - 171Kb)
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Type: Rabbit IgG
 
Applications: ICC; IF
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;
Species Reactivity: R
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Immunogen: Synthetic Met-Enkephalin (H-Tyr-Gly-Gly-Phe-Met-OH) conjugated through N-terminal tyrosine to BSA.
 
Description/Data:

Met-enkephalin is a pentapeptide that appears to enhance immune function at low doses and suppresse at high doses. This molecule acts in the central nervous, neuroendocrine, and immune systems. Cells from these systems have receptors for met-enkephalin and are able to generate met enkephalin from its prohormone, proenkephalin A. Met-enkephalin may be capable of enhancing immune function in cancer or AIDS patients.

It is known to be an endogenous ligand for opioid receptors and acts to mediate analgesia at the spinal level. Met-enkaphalin. Plasma met enkaphalin levels are significantly higher in patients with type I diabetes and could play a role in glucose homeostasis.

Cross-reactivity (%)

  • Met5-Enkephalin                  100
  • Leu5-Enkephalin                    5.8
  • beta-Endorphin                     0.01
  • beta-Lipotropin                     0.01

Image: Immunofluorescent detection of Met-Enkephalin in rat spinal cord dorsal horn (green color).

Related Reagents:

Enkephalin, pre-pro (ppENK)

Leu-Enkaphalin

ACTH

All Opioid Neuropeptide Antibodies

All Pain and Inflammation Antibodies

Diabetes and Obesity Antibodies

References
1.     Stengaard-Pedersen K, Larsson LI. (1981) Histochemistry, 73(1):89-114.
2.     Williams RG, Dockray GJ. (1983) Neuroscience, 9(3):563-586.
3.     Palkovits M. (1984) Progress in Neurobiology, 23:151-189.
4.     Kalivas PW. (1985 ) Neuroscience & Biobehavioral Reviews, 9(4):573-587.
5.     Wang BL, Larsson LI. (1985) Histochemistry, 83(1):47-56.
6.     Moore MR, Black PM. (1991) Neurosurgical Review, 14(2):97-110.