Plexin A3

Affinity Purified Goat Antibody

DATASHEET (pdf - 163Kb)

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Type: Goat IgG

Applications: IHC; WB; E

ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;

Species Reactivity: H; M; R

B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na

Format: Affinity Purified - liquid

Immunogen: Produced in goats immunized with purified, E. coli-derived, recombinant mouse Plexin A3 (rmPlexin A3; aa 34 - 150; Accession # P70208).

Description/Data:

Plexin A3 (also known as SEX) is a 220 kDa member of the Plexin A subfamily of semaphorin receptors. Mature mouse Plexin A3 is predicted to be an 1853 amino acid (aa) type I transmembrane glycoprotein that contains a 1202 aa extracellular domain (ECD) and a 629 aa cytoplasmic region. The ECD contains one semaphorin domain (aa # 34 - 473), three plexin-semaphorin-integrin (PSI) domains (aa # 492 - 830), and four lg-like plexin-transcription factor (IPT) repeats (aa # 841 - 1209). Plexin A3 interacts with neuropilins 1 and 2, and binds class 3 semaphorins. Over aa # 35 - 150, mouse Plexin A3 is 99% and 97% aa identical to rat and human Plexin A3, respectively.

Plexin A3 is involved in the development of neural and epithelial tissues.

Image: Detection of Plexin A3 in mouse embryonic (E13.5) spinal cord. Cells were stained using NorthernLights^TM 577 fluorochrome labeled secondary antibody (red) and counterstained with DAPI (blue).

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