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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| MO15100 | 100 ug | $255.00 | Buy Now | Add to Cart |
Type: Mouse IgG
Applications: IHC; WB; E
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;
Species Reactivity: H; R
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Format: Protein G Purified - liquid
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf 21-derived, recombinant human DDC (rhDDC; aa 1 - 480; Accession # P20711).
Description/Data:
Dopa decarboxylase (DDC), also known as AADC, is a homodimeric vitamin B6-dependent enzyme that catalyzes the decarboxylation of hydroxylated aromatic amino acids (Accession # P20711). DDC is expressed in the adrenal medulla and catecholaminergic neurons. It catalyzes the final step in the synthesis of the neurotransmitters dopamine and serotonin. Defects in DDC are associated with the development of schizophrenia, Parkinson's disease, and hypertension. Human DDC shares 89% aa sequence identity with mouse and rat DDC.
Image: DOPA decarboxylase staining of paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).