Wnts/FZDs/Dkks

Wnt proteins are key regulators of embryonic development. Many receptors and inhibitors influence the Wnt-signaling pathway to ultimately regulate beta-Catenin stability and availability. Understanding Wnt and beta-Catenin signaling and the role of their antagonists (including Frizzled proteins) is important to elucidating the events controlling stem cell organization and maintenance, embryonic development, tissue differentiation, cell adhesion and migration, as well as tumorigenesis and cancer induction and progression.

Dickkopf (Dkk) proteins are negative regulators of Wnt signaling