Type: Mouse IgG
Applications: IHC; WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images; ; HPLC=High Performance Liquid Chromatography; FPLC=Fast Protein Liquid Chromatography
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Format: Protein G Purified - liquid
Immunogen: Prokaryotic recombinant protein corresponding to a 124 amino acid N-terminal region of the cathepsin G molecule.
Description/Data:
Cathepsin G expression in normal tissues is restricted to granulocytes, especially neutrophils. However, mononuclear phagocytes have been demonstrated to bind and internalize proteases from neutrophils. Cathepsin G is located in neutrophilic polymorphonuclear leukocytes which contain specialized azurophil granules together with two other serine proteases; elastase and hepsin. These three proteases may participate in the killing and digestion of engulfed pathogens and in connective tissue remodelling at sites of inflammation. Cathepsin G is also reported to be expressed in acute and chronic myeloid leukemias whereas acute lymphoblastic or chronic lymphocytic leukemias are negative for this protein.
Image: Cathepsin G staining of Human Tonsil. Note intense membrane staining of polymorphonuclear leukocytes. Paraffin section.
