Noggin

Noggin was originally cloned based on its dorsalizing activity in Xenopus embryos and was subsequently found to be a BMP binding protein that antagonizes BMP bioactivities. Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a down growth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor.Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect. In the adult, Noggin is expressed in the central nervous system and in several adult peripheral tissues such as lung, skeletal muscle and skin.

Image: Noggin staining of Cardiac Tissue of 11 d.p.c. Mouse Embryos. Tissue was stained with goat HRP-DAB  (brown) and  counterstained with Hematoxylin (blue).

Other Reagents to Consider:

BMP 2/4

BMP-3

BMP-5

BMP-5 Monoclonal

All Stem Cell Reagents

Neuron/Glial Markers