OPMC-L

Opioid-binding protein/cell adhesion molecule-like (OPCM-L) is a member of the IgLON subfamily in the immunoglobulin protein superfamily. OPCML is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems

Images: Top: OPCM-L immunohistochemical staining of paraffin-embedded human stomach cancer tissue.  Bottom: Western Blot detection of endogenous OPCML proteins from various normal primary cell lysates using OPCML antibody. The predict molecular weight of OPCML is 34 kDa. Due to post-translational modifications, the actual molecular weight of mature OPCML in the SDS-PAGE gel is 51 kDa. HUVEC: Human Umbilical Vein Endothelial Cells; ROb: Rat Osteoblasts.