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CADM1/SynCAM is a brain-specific, immunoglobulin domain. It functions as a homophilic cell adhesion molecule at the synapse. Full-length synCAM has been shown to induce synaptic assembly. It has also been shown that synCAM, in conjunction with glutamate receptors, can sufficiently create a functional postsynaptic response.
The proptein is also involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. In addition, SynCAM plays diverse roles in spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Image: SynCAM Western Blotting in rat brain and HEK cell lysates showing different glycosylation patterns. Brain fractions give banding patterns of a core glycosylation population around 50kDa and a slightly higher glycosylated population around 65 kDa. The heterologous HEK cell lysates give a single, fully glycosylated, band around 107kDa.
Image: Cell were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY CADM1 cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SynCAM