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Type: Mouse IgG
 
Applications: IF; IHC; IP; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Synthetic peptide amino acids 827-845 (SKAESSSKRSFMGPSLKKL) of human TrpC5 (also known as short transient receptor potential channel 5 and Htrp5,
 
Description/Data:
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TRPC5 (Transient receptor potential cation channel, subfamily C, member 5)  is one of 7 mammalian TRPC proteins. It functions as an innocuous cold transducer in nociceptive and thermosensory nerve endings. It plays a role in the activiating the channel for semaphorin 3A-induced neuronal growth cone collapse

Image: TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.

TRPC5 mediated Rho GTPase signaling may cause podocyte damage, and TRPC channels may therefore provide a novel target for anti-proteinuric therapies in acquired, Angiotensin-associated proteinuric disease such as hypertensive and/or diabetic nephropathy.

Note: This antibody has been developed by UC Davis under a grant by NIH.

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Image: Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).

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Image: TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).