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TRPC5 (Transient receptor potential cation channel, subfamily C, member 5) is one of 7 mammalian TRPC proteins. It functions as an innocuous cold transducer in nociceptive and thermosensory nerve endings. It plays a role in the activiating the channel for semaphorin 3A-induced neuronal growth cone collapse
Image: TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.
TRPC5 mediated Rho GTPase signaling may cause podocyte damage, and TRPC channels may therefore provide a novel target for anti-proteinuric therapies in acquired, Angiotensin-associated proteinuric disease such as hypertensive and/or diabetic nephropathy.
Note: This antibody has been developed by UC Davis under a grant by NIH.
Neurotransmission Research Antibodies -GPCRs, Ligand Gated Ion Channels, Biogenic Amines and more
Image: Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).
Image: TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).