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Type: Mouse IgG
 
Applications: ICC; IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (also known as voltage-dependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732).
 
Description/Data:
Picture

Cav1.3 Ca2+ channel or CACN4 encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Cav1.3 voltage-gated L-type calcium channels (LTCCs) translate sound-induced depolarization into neurotransmitter release in auditory hair cells and control diastolic depolarization

Image: Cav1.3 Ca2+ channel staining of adult rat hippocampus.

 

These channels also play a major role in the generation of cardiac pacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells. Genetic knockout or pharmacological inhibition of Cav1.3 reverts this dependency back to HCN and protects these neurons in mouse models of Parkinson’s disease in adult mice.

Note: Antibody has been developed by UC Davis under a grant by NIH.

Picture[2]

Image: Cav1.3Ca2+ channel western blots of adult rat brain membrane.