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CaV2.1 Ca2+ channel (also known as Voltage-gated/dependent T-type calcium channel alpha-1 subunit, and CACNA1C) encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. It binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.
Image: Cav1.2 Ca2+ channel staining of adult rat hippocampus
In the heart, CAV2.1 may be involved in pacemaker current. It also inhibits thalamic sensory transmission to promote sleep. CAV2.1 could play a role in pain processing and neuro-disorders such as migraines, epilepsy and cerebellar ataxias.
Note: This antibody has been developed by UC Davis under a grant by NIH.
Image: Cav2.1 Ca2+ channel western blots of adult rat brain membrane.