|Catalog Number||Size||Price (USD)||Shopping Cart|
|GT41028||100 ug||$250.00 $325.00||Buy Now | Add to Cart|
|P41028||100 ug Blocking Peptide||$145.00||Buy Now | Add to Cart|
TRIM RING finger protein TRIM2, a ubiquitin ligase, is highly expressed in the nervous system. It binds to neurofilament light subunit (NF-L) and regulates NF-L ubiquitination. Deficiencies in TRIM2 increases NF-L level in axons and NF-L-filled axonal swellings in cerebellum, retina, spinal cord, and cerebral cortex.
Image: TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.
These deficiencies eventually lead to neurodegeneration, tremors and ataxia. It is proposed that TRIM2 has neuroprotection properties.
Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes
Apoptosis Research Reagents-includes: detection kits, antibodies and proteins
Image: TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.