|Catalog Number||Size||Price (USD)||Shopping Cart|
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ZIC1 or Zinc finger protein ZIC 1 is a member of the ZIC family of C2H2-type zinc finger proteins. These proteins are particularly important during embryonic development. ZIC1 is a transcriptional activator via interaction with GLI1, GLI2, and GLI3. ZIC1 facilitates development and maturation of the cerebellum and spinal cord during organogenesis of the CNS. Within the pontine gray nucleus (PGN) ZIC1 plays a role in spatial distribution of mossy fiber neurons. The interaction between Zic and Gli family proteins are significant for molecular antagonistic and synergistic factors in development.
Images: ZIC1 staining of immersion fixed frozen sections of mouse brain (cerebellum) using 15 µg/mL of Antibody overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB and counterstained with hematoxylin (blue). Protocol on data-sheet.
This protein is mainly found within the CNS and has high levels of expression in the cerebellum. In cancerous tissue, the ZIC1 protein is often found in medulloblastomas. ZIC1 has been used as a neuroepithelial marker.
Images: Western blot shows lysates of human brain tissue. PVDF membrane was probed with 1 µg/mL of ZIC1 followed by HRP-conjugated Anti-Goat IgG Secondary Antibody. A specific band was detected for ZIC1 at approximately 54 kDa (as indicated). Protocol on data-sheet.