|Catalog Number||Size||Price (USD)||Shopping Cart|
|GT15247||100 ug||$365.00||Buy Now | Add to Cart|
Endoglin (ENG), also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for TGF-beta superfamily ligands. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages.
Image: Endoglin/CD105 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # GT15247) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the 557‑conjugated Streptavidin and counterstained with DAPI (blue)
The role of endoglin in cancer can be contradicting at times since it is needed for neoangiogenesis in tumors, which is needed for tumor growth and survival, yet the reduction in expression of endoglin has in many cancers correlated with a negative outcome of that cancer.
Image (right): Endoglin/CD105 was detected in immersion fixed paraffin-embedded sections of human prostate array using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Antibody (Catalog # GT15247) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP and counterstained with hematoxylin (blue).