The metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that bind with glutamate to activate neurotransmission. The are expressed in neurons, glia and astrocytes.

They are involved in learning, memory, anxiety, and the perception of pain. This receptors are also suspected to play a role in Parkinson's disease.Most recently, Group I mGluRs, have been implicated in the pathogenesis of Fragile X, a type of autism.

Image: Effect of CaMKIIα overexpression on mGluR1a- and mGluR5a- -stimulated ERK1/2 phosphorylation. Shown are representative immunoblots for FL-mGluR1a expression, p-ERK1/2 activity and total-ERK1/2 expression in HEK 293 cells transiently transfected with 3 μg of pcDNA3.1 encoding FLAG-mGluR1a along with 0.5 μg of plasmid cDNA encoding either GFP, GFP-CaMKIIα or GFP-CaMKIIα-T286A in response to 50 μM quisqualate treatment for 0, 5 and 10 min.Molecular Brain 2015, 8:21doi:10.1186/s13041-015-0111-4.

mGluRs are found in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues/.

NameCatalog #TypeSpeciesApplicationsSizePrice
(S)-4-Carboxyphenylglycine323-10AntagonistAllBSM10 mg
50 mg
L-Quisqualic acid188-1AgonistAllBSM1 mg
10 mg
50 mg
O-Phospho-L-serine238-100AntagonistAllBSM100 mg$99
CHPG1049-10AgonistAllBSM10 mg
50 mg