Parkin-2

Parkin-1 and 2 contain an N-terminal ubiquitin-like domain, a linker region, and a C-terminal TRIAD domain consisting of two RING finger motifs flanking a cysteine-rich IBR motif. Mutations in Parkin are a major cause of autosomal recessive juvenile Parkinsonism. Parkin-2 lacks exon 5 which encodes amino acid residues 179 - 206 of Parkin.

Image: Parkin-2 (Parkin isoform 2) staining of paraffin-embedded Human Cerebellum tissue sections.  Tissues were stained using anti-goat HRP-DAB (brown) and counterstained with Haematoxylin (blue). Dilution: 15 µg/mL.