GPRC6A

Affinity Purified Rabbit Antibody
DATASHEET(pdf - 121Kb)
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Type: Rabbit IgG
 
Applications: IHC
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
 
Immunogen: KLH conjugated synthetic peptide- N-terminal extracellular domain of human GPRC6A.
 
Description/Data:
Picture

GPR3, GPR6, and GPR12 make up a family of constitutively active G protein-coupled receptors (GPCRs) that share greater than 50% identity and 65% similarity at the amino acid level and are highly expressed in hippocampus and cortex, regions of the brain . They upregulate cyclic AMP Levels and Promotes Neurite Outgrowth.

GPR3 has been mapped to a chromosomal locus associated with increased risk for Alzheimer’s disease. GPR3 is believed be a factor in accumulation of beta-amyloid (a protein believed to cause the disease).

Image: GPRC6A of Human Skeletal Muscle(paraffin-embedded).

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