FosB

Mouse Monoclonal
DATASHEET(pdf - 71Kb)
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Type: Mouse IgG
 
Applications: WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Immunogen: Recombinant human FosB (aa 1 - 338; Accession #NM_006732)
 
Description/Data:
Picture

FosB is one of four Fos family proteins that associate withJun family proteins to form the AP-1 transcription factor complex.  AP-1 activity is important for gene transcription in a wide variety of cellular processes.


Cancer: Strong differences in the expression pattern of AP-1 family members are present in breast tumors, and that certain members of this family, such as FosB might be involved in the pathogenesis of these tumors.
 
IMAGE: Human HeLa cells were either untreated or treated with TPA for 2 hours and mouse NIH3T3 cells untreated or treated with serum for 1 hour. Total cell lysates were resolved by SDS-PAGE, transferred to Immobilon-P membrane, and immunoblotted with 0.5 ug/ml anti-FosB as described in Protocols for Immunoblotting. A one minute exposure to film is shown. Prominent FosB band is ~ 50Kda. 

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