Network with Neuromics
Contact Information
Neuromics
5325 West 74th St., Suite 8
Edina, MN 55439
Toll free: 866-350-1500
Int'l phone: 952-374-6161
Fax: 612-677-3976
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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| PR27084-2 | 2 ug | $85.00 | Buy Now | Add to Cart |
| PR27084-10 | 10 ug | $185.00 | Buy Now | Add to Cart |
Type: Protein
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Description/Data:
PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signaltransduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling.
References:
1. Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells. Biochem Biophys Res Commun 2007 Nov 9;363(1):165-70
2. Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma. Biochim Biophys Acta 2007 Jul 12;
3. [Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer. Zhonghua Fu Chan Ke Za Zhi 2007 May;42(5):325-9
4. Expression of PTEN protein in patients with laryngeal squamous cell carcinoma. Auris Nasus Larynx 2007 Apr 30;
5. [Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007 Feb;21(3):103-6
6. Immunohistochemical evaluation of PTEN protein in patients with endometrial intraepithelial neoplasia compared to endometrial adenocarcinoma and proliferative phase endometrium. Eur J Gynaecol Oncol 2006;27(4):389-92.
2. Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma. Biochim Biophys Acta 2007 Jul 12;
3. [Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer. Zhonghua Fu Chan Ke Za Zhi 2007 May;42(5):325-9
4. Expression of PTEN protein in patients with laryngeal squamous cell carcinoma. Auris Nasus Larynx 2007 Apr 30;
5. [Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007 Feb;21(3):103-6
6. Immunohistochemical evaluation of PTEN protein in patients with endometrial intraepithelial neoplasia compared to endometrial adenocarcinoma and proliferative phase endometrium. Eur J Gynaecol Oncol 2006;27(4):389-92.
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