PGP9.5 175-191

Whole Serum-Guinea Pig
DATASHEET(pdf - 168Kb)
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Type: Guinea Pig IgG
 
Applications: IHC
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Whole serum - liquid
 
Immunogen: GASSEDTLLKDAAKVCR
 
Description/Data:
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PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

 It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for  cells of the diffuse neuroendocrine system and their tumors

PGP9.5 175-191: Customer Publications 

 

More Links:

PGP 9.5/UCHL1 Antibodies

PGP9.5 Recombinant Protein

Pain and Inflammation Research Antibodies

Neurotransmission Research Antibodies                   

Schwann Cell or PNS Neuronal Markers   

Neurodegenerative Disease Research Antibodies    

Cancer Research Antibodies

Cancer Research Proteins                            

Neuron-Glial Expressed Proteins

Stem Cell Research Reagents

Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes by Category

 

 

  

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Image: PGP9.5 175-191staining of the synovium from ASIC3 +/+ mice with joint inflammation.  Bar = 25 μm. doi: 10.1016/j.pain.2008.01.020.