Ubiquitin+1

Affinity Purified Rabbit Antibody
DATASHEET(pdf - 147Kb)
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Type: Rabbit IgG
 
Applications: IHC; WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
 
Immunogen: KLH coupled synthetic peptide CADLREDPDRQDHHPGSGAQ. The sequence corresponds to the carboxyl terminus of Ubiquitin+1.
 
Description/Data:
Picture

Ubiquitin is a highly conserved protein that is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.

Ubiquitin+1 has a carboxyl terminal amino acid sequence that differs from normal ubiquitin due to a frame shift mutation in the mRNA. This ubiquitin+1 form has been noticed in patients with Alzheimer's and Down's syndrome.

More Links:

Ubiquitin+1 Mouse

Ubiquitin Mouse-Catalog#: MO19005

Ubiquitin-Mouse-Catalog#: MO18001

Ubiquitin Recombinant Protein

Neurodegenerative Disease Research Antibodies

Neurodegenerative Disease Research Recombinant Proteins
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Image: Immunoblots of 2 ng recombinant human Ubiquitin and 2, 1, and 0.5 ng recombinant human Ubiquitin+1. Samples were electrophoresed on 15% gels and immunoblotting was with 1.0 μg/mL anti-Ubiquitin+1. A one minute exposure is shown.