Catalog NumberSizePrice (USD)Shopping Cart
RA1411350 ul$225.00Buy Now | Add to Cart
RA14113100 ul$395.00Buy Now | Add to Cart
P14113100 ug Blocking Peptide$95.00Buy Now | Add to Cart
 
Type: Rabbit IgG
 
Applications: IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Whole serum - liquid
 
Immunogen: (C)EDAEVFKDSMAPGEK; Cys added for conjugation to KLH
 
Description/Data:
Picture

TRPV1 antagonists have shown efficacy in reducing nociception from inflammatory and neuropathic pain models in rats.[11] This provides evidence that TRPV1 is the capsaicin's sole receptor. In humans, drugs acting at TRPV1 receptors could potentially be used to treat neuropathic pain associated with multiple sclerosis, chemotherapy, or amputation, as well as pain associated with the inflammatory response of damaged tissue, such as in osteoarthritis.

Image of VR1 immunoreactivity in mouse dorsal root ganglion. Animals were perfusion fixed with 2% paraformaldehyde. Image courtesy of Dr. Zunyi Wang, University of Wisconsin, Madison.

TRPV1-mouse specific: Customer Data and Publications 

Picture[3]

Images: A Confocal image stack through GCL and NFL of peripheral retina shows TRPV1 in retinal ganglion cell (RGC) bodies (bracket) and in small bundles of RGC axons (arrows). G  top: Western blot against TRPV1 in brain and whole retina from adult rat shows band at expected molecular weight (arrowheads; 100–113 kDa). Retina demonstrates an additional band with a slightly lower molecular weight that probably corresponds to a different glycosylation state for this antibody. bottom: Control Western blot with preabsorption of TRPV1 antibody using the blocking peptide prevents detection of both bands. ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer; NFL, nerve fiber layer. doi:10.1167/iovs.08-2321 on October 24, 2008 (Investigative Ophthalmology and Visual Science. 2009;50:717-728).