|Catalog Number||Size||Price (USD)||Shopping Cart|
|RA14135||100 ul||$275.00||Buy Now | Add to Cart|
Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
Image: TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.
Images: Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.