Patched homolog 2 (PTCH2)

PTCH2 (Patched Family) is a  1203-aa transmembrane protein. It is a possible sonic hedgehog receptor, highly similar to PTCH and containing an SSD domain, that may have a role formation of embryonic structures and in epidermal development. The Drosophila patched-hedgehog signaling pathway establishes segment polarity and anterior-posterior orientation. The patched pathway is conserved from fly to vertebrates. With 56% identity to Patched-1, mouse Patched-2 diverges in the hydrophilic region between transmembrane domains 6 and 7 and in a region of the intracellular C terminus. (NCI)

Image: Detection of PTCH2 in paraffin-embedded human basal cell carcinoma tissue sections  using anti-goat HRP-DAB (brown). Tissues were counterstained with hematoxylin (blue). Dilution-dilution:3 µg/mL.

Flow Cytometry Image: WS-1 human dermal fibroblasts were stained with anti-Patched 2 (grey histogram) or isotype control (open histogram) followed by APC-conjugated anti-goat antibody.