Type: Rabbit IgG
Applications: IHC; WB; FC
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
Immunogen: KLH coupled synthetic peptide derived from the sequence of human Cox2.
Description/Data:
Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.
Image: COX-2 staining of paraffin-embedded human colon carcinoma.
Other Reagents to Consider:
Antibodies:
COX-2-Goat
COX-1
IL; CCR and CXCs
Pain and Inflammation
Neurotrophins and Growth Factors
Proteins:
Interleukins/CXCLs
Transforming Growth Factors
![Picture[2]](/site/special/A8x5babx66x1.jpg)
Right Image: Western blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1 μg/ml for 6 h), using Cox2 Antibody.
![Picture[3]](/site/special/A8x5baex66x1.jpg)
Left Image: Flow cytometric analysis of Raw cells, untreated (blue) or LPS-treated (green), using Cox2 antibody compared to a nonspecific negative control antibody (red).
