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GT15136100 ug$365.00Buy Now | Add to Cart
 
Type: Goat IgG
 
Applications: WB; E
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: NS0-derived rhBACE-1
 
Description/Data:

BACEs (Beta-site APP-Cleaving Enzymes), also named β-secretases, are membrane-bound aspartic proteases of the pepsin family. BACE-1 is the principle beta-secretase responsible for cleavage of amyloid precursor protein (APP) and, therefore, is a potential target for treatment of Alzheimer's disease. BACE-1 is widely expressed and likely has additional functions including the liberation of a membrane-bound sialyltransferase.

It is important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells.