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S100s are calcium binding proteins and are located in the the cytoplasm and/or nucleus of a variety of cell types. S100B is composed of two beta chains, and is involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Some of the extracellular functions of S100B may be mediated by RAGE (receptor for advancedglycation end products). Blood levels of S100B can be used to monitor the extent of brain injury and malignant melanoma.
Image: S100B staining of paraffin-embedded human Alzheimer’s brain tissue sections. Tissues were stained using HRP-DAB(brown) and counterstained with hematoxylin (blue).
S100B: Customer Publications
Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes by Category
Image: Expression of S100B in trigeminal ganglion neurons is increased in response to capsaicin. A section of a ganglion from untreated animals or animals injected with capsaicin stained for S100B is shown. (A) In control ganglion, S100B staining was barely detectable. (B) In contrast, S100B staining was readily detectable in the V3, V2, and V1 regions of the ganglion following capsaicin stimulation for 120 minutes. At higher magnification, increased S100B expression was observed in both neuronal (thick arrows) and satellite glial cells (thin arrows) in response to capsaicin when compared to control (C–E). The same section was stained for DAPI
(C) and S100B (D). A merged image is shown in E. Headache: The Journal of Head and Face Pain, Volume 47, Issue 7, Page 1008-1023, Jul 2007, doi: 10.1111/j.1526-4610.2007.00854.x