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RA1504650 ug$255.00Buy Now | Add to Cart
Type: Rabbit IgG
Applications: ICC; IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
Immunogen: CRGTELDCGIETD (a.a. 163 - 175 of Caspase-3)
Image of Caspase-3 active antibody

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Immunostaining for activated caspase-3 (red) and proteolipid protein (PLP1) in the cortex of P16 msd/Y mutant mouse.  Inset shows DAPI staining for nuclei (top), PLP1 (middle) and activated caspase-3 (bottom). Data Courtesy of Ramaswamy Sharma and Dr. Alexander Gow, Wayne State University.


Image: Detection of active caspase-3 in paraffin-embedded mouse thymus tissue. sections using rabbit anti-human/mouse active caspase-3 affinity-purified antibody. Tissueswere stained using anti-rabbit HRP-DAB (brown color) Cell and Tissue Staining Kit and counterstained with hematoxylin (blue color).