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MO15081100 ug$235.00Buy Now | Add to Cart
 
Type: Mouse IgG
 
Applications: WB; FC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; Pr; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
 
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf21-derived, recombinant human insulysin/insulin degrading enzyme (rhIDE; Accession # NP_004960, aa 42 – 1019). Clone#: 334501.
 
Description/Data:
Picture

Insulysin, a wide expressed protein,  is responsible for the degradation of insulin in cells. Primarily located in the cytosol,  insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.

Figure: HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

 

Other Reagents to Consider:

Insulysin/IDE-Goat

Insulin

Matrix Metalloproteinases (MMPs)

Beta-Amyloid (1-40)

Beta-Amyloid (1-42)

 

All Diabetes and Obesity Antibodies

All Neurodegenerative Disease Antibodies