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Type: Mouse IgG
 
Applications: IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
 
Immunogen: Prokaryotic recombinant protein corresponding to a 124 amino acid N-terminal region of the cathepsin G molecule.
 
Description/Data:
Picture

Cathepsin G expression in normal tissues is restricted to granulocytes, especially neutrophils. However, mononuclear phagocytes have been demonstrated to bind and internalize proteases from neutrophils. Cathepsin G is located in neutrophilic polymorphonuclear leukocytes which contain specialized azurophil granules together with two other serine proteases; elastase and hepsin. These three proteases may participate in the killing and digestion of engulfed pathogens and in connective tissue remodelling at sites of inflammation. Cathepsin G is also reported to be expressed in acute and chronic myeloid leukemias whereas acute lymphoblastic or chronic lymphocytic leukemias are negative for this protein.

Image: Cathepsin G staining of Human Tonsil. Note intense membrane staining of polymorphonuclear leukocytes. Paraffin section.