Insulysin/IDE

Affinity Purified Goat Antibody
DATASHEET(pdf - 189Kb)
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Type: Goat IgG
 
Applications: WB; IP; E
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
 
Immunogen: Purified, Sf 21-derived, recombinant human Insulysin (rhInsulysin; aa 42 – 1019).
 
Description/Data:

Insulysin, a wide expressed protein,  is responsible for the degradation of insulin in cells. Primarily located in the cytosol,  insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.

 

Other Reagents to Consider:

Insulin

Insulysin/IDE Mouse Monoclonal for FC

Matrix Metalloproteinases (MMPs)

Beta-Amyloid (1-40)

Beta-Amyloid (1-42)

 

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