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This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl 2, such as in the case of translocation of Bcl 2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. The Bcl-2 gene has been implicated in a number of other cancers and diseases including: melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. It is also thought to be involved in resistance to conventional cancer treatment. This supports a role for decreased apoptosis in the pathogenesis of cancer
IHC Image: Bcl-2 staining of human breast cancer tissue. Cells were stained using ABC-HRP + NovaRed (red) substrate and Haematoxylin (blue) counterstain. . Nakopoulou, L. et al., Histopathology, 1999, 34(4):310-319.
Apoptosis Research Reagents - Apoptosis Categories-includes: detection kits, antibodies and proteins
WB Image (right): SDS extracts from 3 x 106 human KGI and 1 x 106 mouse MNFS60 cells were also electrophoresed on the gel. After transfer to membranes, the samples were blotted with anti-Bcl-2. Methods are described in the attached protocol.
IP Image (left): SDS extracts from 3 x 106 human KGI and 1 x 106 mouse MNFS60 cells were also electrophoresed on the gel. After transfer to membranes, the samples were blotted with anti-Bcl-2.