Type: Mouse IgG
Applications: IHC; WB; E
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf 21-derived, recombinant human DDC (rhDDC; aa 1 - 480; Accession # P20711).
Dopa decarboxylase (DDC), also known as AADC, is a homodimeric vitamin B6-dependent enzyme that catalyzes the decarboxylation of hydroxylated aromatic amino acids (Accession # P20711). DDC is expressed in the adrenal medulla and catecholaminergic neurons. It catalyzes the final step in the synthesis of the neurotransmitters dopamine and serotonin. Defects in DDC are associated with the development of schizophrenia, Parkinson's disease, and hypertension. Human DDC shares 89% aa sequence identity with mouse and rat DDC.
Image: DOPA decarboxylase staining of paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).