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The glycine receptor (GlyR) chloride channel is a member of the nicotinic acetylcholine receptor family of ligand-gated ion channels. Its glycine-mediated activation results in an influx of chlorine ions that hyperpolarize and desensitize neuronal postsynaptic membranes. There are at least five GlyR subunits (four alpha-type and one beta-type) that form homo- or heteromultimers. Alpha1-beta multimers may be the principal synaptic GlyR in adults.
Image: Western blot of 10 μg of rat spinal cord. As shown in the autoradiograph, the Anti-Glycine Receptor antibody is specific for the ~48 kDa subunits recognizing both the α1 and α2 subunits of the Glycine Receptor.
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