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RA25029100 ul$295.00Buy Now | Add to Cart
 
Type: Rabbit IgG
 
Applications: WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Peptide corresponding to residues surrounding Thr668 of human APP695
 
Description/Data:
Picture

Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.

Image: Western blot analysis using FE65 and HEK 293 cell lysates

Related Reagents to Consider:

APP

APP 228

Phospho-APP

ABCA1 (MO13101)

ADAM10 (Human) (GT15078)

ADAM10 (Mouse) (GT15079)

Abeta 40 (RA25009)

BACE-1 (MO15066)

BACE-1 (GT15132)

APP (RA18003)

Tau (Tau 46)

CLAC-P (NC2-1 Region) (RA19007)

CLAC-P (NC2-2 Region) (RA19008)

CLAC-P (NC3-3 Region) (RA19009)

Presenilin 1 (RA18020)

Presenilin 1 (GT15027)

Presenilin 2 (RA18004)

alpha-Synuclein (MO15053)

alpha-Synuclein (RA18021)

WWOX (RA19025)

Apoptosis Reagents

Transfection Reagents

 Primary Neurons

 

Transfection Reagents

Neural Stem Cell Reagents