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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| RA18004 | 100 ul | $310.00 | Buy Now | Add to Cart |
Type: Rabbit IgG
Applications: ICC; IHC; WB; IP
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5;
Species Reactivity: H; M; Pr; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
Immunogen: Peptide corresponding to residues surrounding amino acid 330 of human presenilin 2
Description/Data:
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
Image: Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc.
More Links:
| Apoptosis Research Reagents-Apoptosis Categories-includes: detection kits, antibodies and proteins
Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes
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