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Type: Mouse IgG
Applications: IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein A purified - Ascites Fluid
Immunogen: insect cell line Sf 21-derived, recombinant human interleukin 2 soluble receptor alpha (rhIL-2 sRAlpha).

Human IL-2 R alpha, also known as Tac antigen and as CD25, is a 272 amino acid (aa) precursor type I membrane protein with a 21 aa signal peptide, a 219 aa extracellular region, a 19 aa transmembrane region, and a 13 aa cytoplasmic domain. By itself, IL 2 R alpha binds IL-2 with low affinity. However, when IL-2 R alpha is associated with IL-2 R beta and the common gamma chain, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed.

Image: IL-2 Rα staining of frozen tissue sections of human lymph node. Tissue sections were stained using anti-mouse ABC-HRP, NovaRed (red) substrate and Haematoxylin (blue) counterstain.