mGluR6

Affinity Purified Rabbit Antibody
DATASHEET(pdf - 90Kb)
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Type: Rabbit IgG
 
Applications: ICC; IHC; WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
 
Immunogen: AAPPQNENAEDAK
 
Description/Data:
Picture[2]Picture[4]

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.

IHC Image: Staining of mouse nob rescue retinal sections.  

WB Image: Mouse retinal lysates. Courtesy of Megan A. Foreman, University of Birmingham.

mGluR6-Customer Data and Publications.

Note: A customer found a band in the 60-70 kDa range corresponding to the mGluR6 precursor.

 

More Links:

mGluR6-Rabbit-Catalog#: RA30046

mGluR6-Guinea Pig

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Vision and Retina Research Antibodies

Primary Neurons and Astrocytes -Primary human, rat and mouse neurons and astrocytes by Category

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Image: mGluR6 staining of GluR6 in trapezoid body in mouse brain using anti-rabbit Cy3 conjugated secondary antibodies (red color). DAPI was used to counterstain cell nuclei. Dilution 1:30. Tissue was mounted to slide using i-BRITE Plus anti fade media.

 

Picture[4]

Image: mGluR6 (green) and protein kinase C (green) staining of P100 rat retinas. (mGluR6 dilution 1:2000). Raymond D. Lund, Shaomei Wang, Bin Lu, Sergej Girman, Toby Holmes, Yves Sauvé, Darin J. Messina, Ian R. Harris, Anthony J. Kihm, Alexander M. Harmon, Feng-Yi Chin, Anna Gosiewska, Sanjay K. Mistry. Cells Isolated from Umbilical Cord  Tissue Rescue Photoreceptors and Visual Functions in a Rodent Model of Retinal Disease. Stem Cells Vol. 25 No. 3 March 2007, pp. 602 -611 doi:10.1634/stemcells.2006-0308; www.StemCells.com © 2007 AlphaMed Press