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Type: Rabbit IgG
 
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: Pr; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - lyophilized
 
Immunogen: YPFF conjugated to BSA
 
Description/Data:
Image Endomorphin 2 or END-2 Antibody staining of Rat DRGs

Endomorphins are recently discovered endogenous opioid peptides composed of four amino acids: Endomorphin-1 (EM-1) is Tyr-Pro-Trp-Phe-NH2, and  Endomorphin-2 (EM-2) is Tyr-Pro-Phe-Phe-NH2. These peptides have a very high affinity and specificity for mu-opioid receptors as it has been reported in many pharmacological studies. EM-1 is distributed in many brain regions, whereas EM-2 is prevalent in brainstem and spinal cord.  EM-1 and EM-2 exert their antinociceptive activity by interacting with mu-opioid receptors. EM-1 anf EM-2 bind with mu-opioid receptor with high affinity and selectivity in comparison with binding to opioid delta and kappa receptors. EM-1 and EM-2 tetrapeptides activate G-proteins and inhibit adenylyl cyclase activity when bind to mu-opioid receptors.

Image: Endomorphin-2 Staining in rat dorsal horn.

Note: Our affinity-purified anti END-1 antibody  label neuronal fibers in various brain regions including (but not limited to) thalamic nuclei, periaqueductal gray matter, amygdala, locus coeruleus, nucleus accumbens, parabrachial nucleus, nucleus tractus solitarius and septum. Our affinity-purified anti EM-2 antibodies label neuronal processes in spinal cord dorsal horn and trigeminal tract, and label neuronal cell bodies in thalamus. END-1 and 2 distribution in brain overlaps with mu-opioid receptors.

Image of Endomorphin-2 and END-2 staining of neurons from neonatal rat lumbar (L4/5) DRG

Image: END-2 staining of neurons from neonatal rat lumbar (L4/5) DRG. doi: 10.1111/j.1460-9568.2008.06238.x.