Mu Opioid Receptor

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability.

Note: The current lot (401268) of this antibody shows less intense staining in spinal cord tissue vs. previous lots.

Western Blot Protocol

Mu Opioid: Customer Data and Publications

Images:  Double immunofluorescence labeling showing the presence of a subpopulation of spinal lamina II neurons that contained both µ opioid receptor (green) and TRPV1 (red) immunoreactivity in a vehicle (A)- and a RTX (B)-treated rats. Co-localization of the µ opioid receptor and TRPV1 immunoreactivity is indicated in yellow when 2 images are digitally merged. All images are single confocal optical sections. Scale bar, 20 µm. J Neurophysiol 95: 3086-3096, 2006. First published February 8, 2006; doi:10.1152/jn.01343.2005
0022-3077

Image: MOR staining of Rat DRG (dilution: 1:100) incubation at 4 °C overnight. Secondary antibody is anti-Rabbit Rhodamine Red (dilution:1:200) incubation at room temperature for 1 hour.