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Type: Rabbit IgG
 
Applications: IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Synthetic peptide made to a C-terminal portion of the rat protein (within residues 1430-1508). [Swiss-Prot# Q5G856].
 
Description/Data:
Picture

TRPM2 is a member of the melastatin-related TRPM subfamily belonging to the transient receptor potential or TRP channel superfamily. TRPM2 can form a Ca2+-permeable cationic channel activated by intracellular ADP-ribose. The physiological functions of TRPM2 remain largely unknown except that activation of TRPM2 channel can initiate yet unidentified signalling cascades that lead to membrane disruption and eventually cell death.

 

Image: TRPM2 (red) and GFAP (green) staining of rat hippocampus. Nclei staining is blue. Image courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand.

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Image: Detection of TRPM2. Lane 1: CHO cells untransfected. Lane 2: CHO cell transfected with rat TRPM2 Lane 3: Mouse cortical neurons (cultured).  Photo courtesy of Dr. Paco Herson, Oregon Health & Science University.