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Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.
Image: COX-2 staining of paraffin-embedded human colon carcinoma.
Human Osteoblasts-Derived from hMSCs
Right Image: Western blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1 μg/ml for 6 h), using Cox2 Antibody.
Left Image: Flow cytometric analysis of Raw cells, untreated (blue) or LPS-treated (green), using Cox2 antibody compared to a nonspecific negative control antibody (red).