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Type: Rabbit IgG
 
Applications: ICC; IF
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Immunogen: Synthetic Met-Enkephalin (H-Tyr-Gly-Gly-Phe-Met-OH) conjugated through N-terminal tyrosine to BSA.
 
Description/Data:
Picture

Met-enkephalin is a pentapeptide that appears to enhance immune function at low doses and suppresse at high doses. This molecule acts in the central nervous, neuroendocrine, and immune systems. Cells from these systems have receptors for met-enkephalin and are able to generate met enkephalin from its prohormone, proenkephalin A. Met-enkephalin may be capable of enhancing immune function in cancer or AIDS patients.

It is known to be an endogenous ligand for opioid receptors and acts to mediate analgesia at the spinal level. Met-enkaphalin. Plasma met enkaphalin levels are significantly higher in patients with type I diabetes and could play a role in glucose homeostasis.

Cross-reactivity (%)

  • Met5-Enkephalin                  100
  • Leu5-Enkephalin                    5.8
  • beta-Endorphin                     0.01
  • beta-Lipotropin                     0.01

Image: Immunofluorescent detection of Met-Enkephalin in rat spinal cord dorsal horn (green color).

References
1.     Stengaard-Pedersen K, Larsson LI. (1981) Histochemistry, 73(1):89-114.
2.     Williams RG, Dockray GJ. (1983) Neuroscience, 9(3):563-586.
3.     Palkovits M. (1984) Progress in Neurobiology, 23:151-189.
4.     Kalivas PW. (1985 ) Neuroscience & Biobehavioral Reviews, 9(4):573-587.
5.     Wang BL, Larsson LI. (1985) Histochemistry, 83(1):47-56.
6.     Moore MR, Black PM. (1991) Neurosurgical Review, 14(2):97-110.