|Catalog Number||Size||Price (USD)||Shopping Cart|
|RA24287||100 uL||$375.00||Buy Now | Add to Cart|
|P24287||50 ug Blocking Peptide||$95.00||Buy Now | Add to Cart|
Human nitric oxide synthases are a family of enzymes responsible for the synthesis of nitric oxide from L-arginine and molecular oxygen. There are at least three nitric oxide synthases; NOS I, also known as neuronal NOS or nNOS, NOS II, which is referred to as inducible NOS or iNOS and NOS III, also known as endothelial NOS or eNOS. nNOS plays a role in the upregulation of microglial phospho-p38 MAPK. Such p38 MAPK activation in microglia is consistent with a potential role in the development of morphine antinociceptive tolerance.
Image: nNOS staining of rat brain.
nNOS is expressed in the hypothalamus, striatum, cortex, spinal cord and PNS. In ischemic stroke, nNOS activation is linked to Neural Damage.
Neurotransmission Research Antibodies-GPCRs, Ligand Gated Ion Channels, Biogenic Amines and more
Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes