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CH23023100 ul$125.00Buy Now | Add to Cart
 
Type: Chicken IgY
 
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Synthetic peptides corresponding to different regions of the metabotropic glutamate receptor type 1 gene product but are shared between the human (NP_000829.2, NCBI) and mouse (NP_058672.1, NCBI) sequences.
 
Description/Data:
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Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells

Image: Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (red). Protocol on datasheet.

mGluR1 modulates excitatory and inhibitory synaptic transmission in various brain areas including the activation of glutamate-driven synaptic inhibition in the cerebellum. mGluR1 and other mGluRs have emerged as therapeutic targets for neuropsychiatric disorders associated with cortical dysfunction and the modulation of nociceptive and neuropathic pain.