Human MIP-1 beta (macrophage inflammatory protein 1 beta) is the product of several independently cloned cDNAs including Act 2, PAT 744, hH400, G26, HIMAP, HC21, and MAD-5a. MIP-1 beta is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 beta is expressed primarily by T cells, B cells, and monocytes after antigen or mitogen stimulation. The functional receptor for MIP-1 beta has been identified as CCR5.
Image: Paraffin-embedded tissue sections of human hippocampus (Alzheimer's). MIP-1 beta immunoreactivity is shown in red and Haematoxylin counterstain in blue.