FOXC1

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Image: FOXC1 staining of paraffin embedded Human Kidney (dilution (3µg/ml) . Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. Protocol on Data-sheet.

Image: FOX1C staining (dilution: 0.5µg/ml)of Human Bone Marrow lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.