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In vertebrates, GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. Two general classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex, and GABAB metabotropic receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries (G proteins).

Image: GABA A Receptor alpha 4 (dilution: 2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

NameCatalog #TypeSpeciesApplicationsSizePrice
GABA A receptor alpha 4GT41008Rabbit IgGH; RIHC; WB; E100 ug
100 ug Blocking Peptide
$250
$145
GABA A Receptor beta 3GT41011Goat IgGHIHC100 ug
100 ug Blocking Peptide
$310
$145
GABA A Receptor beta 3MO50001Mouse IgGH; M; RICC; IHC; WB100 ul$349
GABA A Receptor, delta subunitMO50002Mouse IgGM; RIF; IHC; WB100 ul$349
GABA A receptor, pi subunitRA30047Rabbit IgGH; M; RIHC; WB; E50 ug$560
GABA B Receptor1RA20003Rabbit IgGH; RIHC100 ul$245
GABA B Receptor2GT15009Goat IgGRICC; IHC; WB; E100 ug$365
GABA Receptor Associated ProteinRA19014Rabbit IgGH; M; RWB100 ug$250
GAD1/GAD67GT15142Goat IgGH; M; RIHC; WB; E100 ug$365
GAT-2RA24459Rabbit IgGRIHC100 ul$399